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PGS
Preimplantation Genetic Screening

Now known as PGT-A (Preimplantation Genetic Testing for Aneuploidies)

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Overview

  • PGS (PGT-A) is a genetic test performed on embryos to identify numerical chromosomal abnormalities (aneuploidy).
  • The test is performed on embryos prior to transfer into the uterus.
  • By analyzing all embryos generated in an IVF treatment cycle, those free of chromosomal aneuploidy can be selectively transferred.
  • As a result, the pregnancy rates per transfer are significantly increased and the miscarriage rates decreased.
Overview

Benefits

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Increases pregnancy rates per transfer

Selecting normal embryos can increase the pregnancy chances after transfer.

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Reduction in
miscarriage rate

In the general population, 25% of all clinical pregnancies 
end in miscarriage.

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Increase in the likelihood
of having a healthy baby

Some pregnancies with chromosomal anomalies can give rise to the birth of a baby with a serious illness.

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Reduction in time and necessary resources

The time and resources necessary to achieve a pregnancy are reduced. 

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Reduces risk of multiple pregnancy

Increases the chance of pregnancy following a single embryo transfer.

According to internal data and several independent clinical studies, selecting normal embryos might increase the pregnancy possibilities after transfer.

Tabla PGS web

In the general population, 25% of all clinical pregnancies end in miscarriage and almost half are chromosomally abnormal.

Therefore, especially in high-risk groups, the PGT-A reduces the risk of misscarriage.

Indice of aneuploid blastocysts according to maternal age

The PGT-A increases the possibility of having a healthy baby, as it allows chromosomally normal embryos to be identified.

The mean theoretical time to achieve a LB (weeks) decreases from 14.9 to 7.7 weeks with PGS (1)

Percentage of PGS cases with at least one normal embryo for transfer according to maternal age

PGT-A helps to avoid repeating cycles of assisted reproduction and can help to reduce the number of multiple pregnancies performing by supporting single embryo transfer

Indications

Indications

  • Advanced maternal age: 35 years or above
  • Recurrent miscarriages: 2 or more miscarriages of unknown cause
  • Assisted reproduction cycles without pregnancy: 2 or more assisted reproduction cycles without pregnancy result
  • Male factor: Males with low sperm concentration, below 5 million per ml
  • Previous pregnancies with anomalies: 1 previous pregnancy with chromosome abnormality, especially in an assisted reproduction cycle

Technology

We use the most advanced technology, NGS (Next-Generation Sequencing) to perform the PGS (PGT-A):

  • Ability to detect aneuploidies, mosaicism and segmental alterations
  • Rapid technology allowing embryos to be transferred in fresh or frozen cycles
  • New diagnostic possibilities including the measurement of mitochondrial DNA copy number (MitoScore)
  • Best cost-effective ratio
  • High flexibility and scalability of the samples

Our technology and experience allows us to analyze 24 chromosomes in a 12-hour procedure which provides results in more than 99% of cases.

Technology

Methodology

Methodology

Elective Single Embryo Transfer (SET)

Twin pregnancy is associated with more pregnancy complications and poorer pregnancy outcome than singleton pregnancy.

The development of the IVF techniques and recent studies* demonstrate:

  • No statistical difference in pregnancy rates achieved by Single Embryo Transfer compared with Multiple Embryo Transfer
  • A reduction in multiple pregnancies

*Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. (Sills ES, Salem RD. 1. Mol Cytogenet. 2012 May 2;5(1):24.)

More info
Optional Single Embryo Transfer (SET)

Multiple pregnancy has increased risks for the mother and the babies:

  • Hypertensive disorders of pregnancy
  • Cord prolapse
  • Malpresentation
  • Premature rupture of membrane
  • Increased rate of cesarean section
  • Low Apgar scores
  • Perinatal death

Barri PN, Coroleu B, Clua E, Tur R. Prevention of prematurity by single embryo transfer. J Perinat Med. 2011 May;39(3):237-40.

 

References

Scientific publications and documents.

PGS (PGT-A) publications

PGS (PGT-A) Specialists Brochure

1: Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Fertil Steril. 2017 May;107(5):1122-1129.

2: Rubio et al: Preimplantation genetic screening using fluorescence in situ hybridization inpatients with repetitive implantation failure and advanced maternal age: two randomized trials.
Fertil Steril. 2013 Apr;99(5):1400-7.

3. Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study.
Mol Cytogenet 2012 May 2; 5(1):24.

4. Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, Ata B, Cohen J, Munné S. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial.
Fertil Steril. 2017 Mar;107(3):723-730.e3.

5. Coates A, Bankowski BJ, Kung A, Griffin DK, Munne S. Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following preimplantation genetic screening (PGS): a single center retrospective study.
J Assist Reprod Genet. 2017 Jan;34(1):71-78.

Our results

We are proud to deliver high quality results for every test, every day. Our experts are professional, reliable and approachable and are available to help guide both professionals and patients throughout the entire process.

60k

embryos analysed/year

12k

IVF cycles/year

20+

years experience 
in genetics

99%

accurate

Become our provider

We will help you get started quickly and efficiently

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