ERA - Canada

Overview

ERA
Benefits
Indications

What is the ERA Test?

The Endometrial Receptivity Analysis (ERA), developed and patented by Igenomix (PCT/ ES2009/000386), is a test designed to evaluate endometrial receptivity.
The ERA test has been shown to be highly sensitive and specific in the detection of genetic expression profiles associated with receptivity. It allows a patient’s personalized window of implantation to be detected and applied to their future frozen embryo transfers.

What is the procedure?

The ERA utilizes RNA obtained from an endometrial tissue sample. The RNA analyzed and then classified by our ERA predictor as receptive or non-receptive, depending on the expression profile of the RNA.
If the endometrium is non-receptive, the test enables us to find a personalized window of implantation for each patient in the majority of cases.

Why use ERA test?

This molecular diagnostic tool uses NGS to analyze the expression level of 248 genes related to the status of endometrial receptivity.
The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.
ERA is backed by 33 publications; 29 from Igenomix and 4 external publications.
Proprietary algorithm based on machine learning that minimizes the need for second biopsy (90% of cases).
Allows clinicians to identify transition phases with 12 hours shifts.
Randomized clinical trial (NCT01954758) RCT proves cumulative live birth rate increases +16 points VS classic frozen blastocyst transfer in first appointment patients:

Who should use ERA test?

Women who have experienced implantation failure with morphologically good quality embryos.
Women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), where the uterus and endometrium are unlikely to be the problem.

When to perform ERA to your Patient?

When is a second biopsy needed?

90 % of cases don’t need a second biopsy. The second biopsy is only required under two circumstances:

Patients with a “Pre-receptive 2 days” result.
Patients with a “Post-receptive” result.

The development of the ERA diagnostic tool was published in the paper by Díaz-Gimeno et al, 2011 (Fertil Steril. 2013 Feb; 99(2):508-17).

ERA´s effectiveness and consistency were demonstrated in the paper by Díaz-Gimeno et al, 2013 (Fertil Steril. 2013 Feb; 99 (2): 508-17).

ERA clinical applicability to patients with implantations failure was demonstrated in a publication by Ruiz-Alonso et al, 2013 and 2014.

What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study Ruiz-Alonso M. et al, 2014. (Hum Reprod. 2014 Jun;29(6):1244-7)

A randomized study is currently in progress to assess its applicability to patients without any prior assisted reproduction treatment (ClinicalTrials.gov Identifier: NCT01954758).

The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers. Tan J, Kan A, Hitkari J, Taylor B, Tallon N, Warraich G, Yuzpe A, Nakhuda G. J Assist Reprod Genet. 2018 Jan 11. doi: 10.1007/s10815-017-1112-2. [Epub ahead of print]

Combinatorial use of Endometrial Receptivity Array (ERA) and PGT-A can improve the clinical outcome in cases with previous ART failures. N. Findikli, M. Gultomruk, K. Boynukalin, M. Kavrut, E. Oral, M. Bahceci. ESHRE Oral communication.

Pregnancy outcomes in patients undergoing embryo transfer in cycle following endometrial receptivity assay. M. Pasternak, G. Schattman, Z. Rosenwaks. ASRM Poster.

The implantation rate of Japanese infertile patients with repeated implantation failure can be improved by endometrial receptivity array (ERA) test: A randomized controlled trial. S. Taguchi, M. Funabiki, T. Hayashi, Y. Tada, Y. Iwaki, M. Karita, T. Ota, K. Maeda, T. Matsubara, P. Zada, N. Sugiyama, Y. Nakamura. ASRM Oral communication.

Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two-centers study. Hashimoto T, Koizumi M, Doshida M, Toya M, Sagara E, Oka N, Nakajo Y, Aono N, Igarashi H, Kyono K. Reprod Med Biol. 2017 Jun 27;16(3):290-296. doi: 10.1002/rmb2.12041. eCollection 2017 Jul. PMID:29259480

Assessment of endometrial receptivity by endometrial receptivity array (ERA) in patients with adenomyosis and previous implantation failure in IVF. Kaur S, Mahajan N, Rani K, Naidu P, Kaur J. ESHRE Poster.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

Endometrial Receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles. A.M. Propst, L. Hansard, K. Silverberg, M. Hegtvedt, N.Z. Burger, T.C. Vaughn. ASRM Poster.

Endometrial receptivity array: Clinical application. Mahajan N. J Hum Reprod Sci. 2015 Jul-Sep;8(3):121-9. doi: 10.4103/0974-1208.165153. Review. PMID:26538853.

Live birth after embryo transfer in an unresponsive thin endometrium. F. Cruz, J. Bellver. Gynecol Endocrinol. 2014 Jul;30(7):481-4. doi: 10.3109/09513590.2014.900747. Epub 2014 Mar 20.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

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We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

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Robust randomized clinical study results

Backed by 33 publications

30% of patients have a displaced window of implantation

+55.000 patients in 60 countries already use ERA

Are you interested?

What is the ERA Test?

What is the procedure?

Why use ERA test?

Who should use ERA test?

When to perform ERA to your Patient?

When is a second biopsy needed?

Test limitations

Clinical Sheets

Brochure

French Brochure

Relevant related studies:

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

EndomeTRIO

EMMA

ALICE

ERA® Endometrial Receptivity Analysis

The ERA test evaluates the patient’s endometrial receptivity to determine their unique window of implantation.

Robust randomized clinical study results

Backed by 33 publications

30% of patients have a displaced window of implantation

+55.000 patients in 60 countries already use ERA

Are you interested?

What is the ERA Test?

What is the procedure?

Why use ERA test?

Who should use ERA test?

When to perform ERA to your Patient?

When is a second biopsy needed?

Test limitations

Clinical Sheets

Brochure

French Brochure

Relevant related studies:

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

Other services

EndomeTRIO

EMMA

ALICE

Igenomix is in the media