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SAT

Sperm Aneuploidy Test

Analysis of sperm chromosomal abnormalities

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Overview

  • SAT is a diagnostic test to study the genetic etiology of male infertility.
  • It allows us to evaluate the presence of an abnormal number of chromosomes in the sperm.
  • In couples with severe male factor infertility, there is a higher risk of transmission of sperm chromosomal abnormalities to the offspring.

More Info

Overview

Benefits

  • Increases pregnancy rate.
  • Decreases miscarriage risk.
  • Identifies sperm with a low chance of reproductive success.
  • Useful tool to provide personalized genetic counseling to the infertile couple before their IVF treatment.

For couples with an abnormal SAT, it is recommended to perform PGT-A (Preimplantation Genetic Testing - Aneuploidy) to select chromosomally normal embryos for transfer.*
*Rodrigo et al., 2014.

Indications

  • Male factor infertility: low sperm concentration is correlated with a higher incidence of sperm chromosomal abnormalities
  • Recurrent miscarriage of unknown etiology.
  • Repetitive implantation failure.
  • Previous pregnancy with a chromosomal abnormality.
Indications

Methodology

Main steps of the assay

Results

An increase of sperm chromosomal abnormalities affects reproduction on 3 levels.

EMBRYO LEVEL

  • Sperm with sex chromosome abnormalities results in aneuploid embryos.
  • Diploid sperm result in triploid embryos.

(Rodrigo et al., 2010)

PREGNANCY LEVEL

  • An elevated SAT decreases pregnancy rates after ICSI and increases miscarriage rate.

(Rubio et al., 2001)

OFFSPRING LEVEL

  • An elevated SAT increases the risk of abnormal offspring.

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